efficient ball mill procedure in the aldol reaction

Efficient ball-mill procedure in the ‘green’ asymmetric ...

Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water

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A Highly Efficient Asymmetric Organocatalytic Aldol ...

2007-1-25  A Highly Efficient Asymmetric Organocatalytic Aldol Reaction in a Ball Mill. Rodriguez, Belen; Bruckmann, Angelika; Bolm, Carsten 2007-01-25 00:00:00 ChemInform Abstract The proline‐catalyzed solvent‐free aldol reaction of alicyclic and aliphatic ketones (I), (V) and (VII) with aromatic aldehydes (II) is significantly accelerated by ball milling.

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A Highly Efficient Solvent-Free Asymmetric Direct

2021-3-12  Recoverable (S a)-binam-l-prolinamide in combination with benzoic acid is used as catalysts in the direct aldol reaction between cycloalkyl, alkyl, and α-functionalized ketones and aldehydes under solvent-free reaction conditions. Three different methods are assayed: simple conventional magnetic stirring, magnetic stirring after previous dissolution in THF and evaporation, and ball mill technique.

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A Highly Efficient Asymmetric Organocatalytic Aldol ...

2007-5-22  Abstract. Anti ‐aldol products with up to >99 % enantiomeric excess ( ee) have been obtained by proline catalysis in excellent yields under experimentally simple solvent‐free conditions. Efficient mixing of all the components is accomplished by applying a mechanochemical technique (ball milling). The catalysis is air and moisture tolerant and can ...

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Proline−β3-Amino-Ester Dipeptides as Efficient

2019-12-12  Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water. Tetrahedron 2011 , 67 (36) , 6953-6959.

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The Ion Tag Strategy as a Route to Highly Efficient ...

José G. Hernández and Eusebio Juaristi, Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water, Tetrahedron, 67, 36, (6953), (2011).

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Ball Milling - University of Massachusetts Boston

2020-4-9  Mixer Mill MM 400. 11. Feed material: hard, medium-hard, soft, brittle, elastic, fibrous Material feed size: ≤ 8 mm Final fineness: ~ 5 µm Setting of vibrational frequency: digital, 3 - 30 Hz (180 - 1800 min-1) Planetary Mills.

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Bio-renewable enantioselective aldol reaction in

2015-11-5  General procedure for the aldol reaction in a deep eutectic solvent To around 1 mL of the corresponding solvent in a vessel under an argon atmosphere, l-proline (0.035 g, 30 mol%) and the corresponding aldehyde (1 mmol) were added. Then the

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[PDF] Use of (R)-Mandelic Acid as Chiral Co-Catalyst in ...

Efficient ball-mill procedure in the 'green' asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water J. G. Hernández , E. Juaristi Chemistry

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KF/Nano-clinoptilolite Catalyzed Aldol-Type Reaction

2017-8-23  The reaction is efficient for variety of aliphatic and aromatic aldehydes, giving α-diazo carbonyl compounds in moderate to high yields. Both electron-rich and electron-deficient aldehydes worked well, affording the desired products in good to high yields.

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A highly efficient asymmetric organocatalytic aldol ...

A highly efficient asymmetric organocatalytic aldol reaction in a ball mill. Rodríguez B(1), Bruckmann A, Bolm C. Author information: (1)Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52056 Aachen, Germany.

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Ball Milling - University of Massachusetts Boston

2020-4-9  Ball Milling An efficient and ecologically friendly synthetic approach ... What is ball milling? A ball mill is a type of grinder used to grind materials into extremely fine powder. 7 . Major parameters for ball milling Temperature ... Aldol Condensations

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Natural low-molecular mass organic compounds with

2014-12-2  Hernández JG, Juaristi E. Efficient ball-mill procedure in the ‘green’ asymmetric aldol reaction organocatalyzed by (S)-proline-containing dipeptides in the presence of water. Tetrahedron. 2011; 67 (36):6953–6959.

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Bio-renewable enantioselective aldol reaction in

2015-11-5  Organic chemists solved quickly the problem of pollutants by performing the reaction under solvent-free conditions. 7 A similar reaction performed under ball mill conditions gave the same aldol product 3a in 73% yield and 56% ee. 8 However, in

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KF/Nano-clinoptilolite Catalyzed Aldol-Type Reaction

2017-8-23  Nano-sized natural clinoptilolite zeolite was prepared by grinding in a planetary ball mill using a zirconia vial set in dry conditions with a time period of about 20 min. The KF/CP NPs catalyst was prepared according to our previously reported procedure . Thus, 1 g of KF was dissolved in distilled water (10 ml) and nano-clinoptilolite (9 g).

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in Organic Synthesis under Solvent-Free Reaction

2020-8-6  One of the most thoroughly studied organocatalytic reactions is the aldol reaction, since it constitutes one of the most useful strategies for the formation of C-C bonds. In a seminal work reported in 2006, Bolm et al. carried out asymmetric aldol reactions by means of chiral organocatalysts in a ball mill with excellent results [57,58].

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Mechanochemistry: An efficient method of solvent

2014-1-1  3-Amino-2,4-dicarbonitrile-5-methylbiphenyls are synthesized by a three-component reaction of aromatic aldehydes, malononitrile, and acetone in the presence of catalytic NaOMe under grindstone method. The yields are excellent; the procedure is simple, efficient, and environmentally benign; and all the reactions go to completion within 2–3 min.

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Organocatalysis in aqueous media Nature Reviews

2019-7-17  Another remarkable enzyme-inspired aldol reaction involves the organocatalyst–cyclodextrin hybrid 13 (Supplementary Table 1, reaction 4b), which promotes asymmetric direct aldol reactions with ...

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许丹倩 - 浙江工业大学 - 化学工程学院 - X-MOL

IF:4.45 (4) An Organocatalytic Domino Thia-Michael/Aldol Condensation Reaction: Highly Enantioselective Synthesis of Functionalized Dihydrothiophenes, Adv. Synth. Catal., 2010, 352, 2121. IF:6.048 (5) Fast, solvent-free and hydrogen-bonding-mediated asymmetric Michael addition in a ball mill, Green Chem., 2012, 14 (4), 893.

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许丹倩_百度百科

2006-7-26  许丹倩 博士、研究员、博士生导师。1963年出生,1989年毕业于华东师范大学。1992年至今,浙江工业大学任教。主要学术荣誉称号: 省“151人才工程”第一层次。

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Supplementary Information - RSC

2013-6-28  published HPLC retention times. Reactions in the ball mill were conducted using a Fritsch Planetary Micro Mill model “Pulverisette 7”. Typical procedure for the solvent-free asymmetric aldol reaction between cyclohexanone and 4-nitrobenzaldehyde in a ball mill: A mixture of (S,S,S,S,S,S)-1 (0.13 g, 0.02 mmol), CoBr 2

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in Organic Synthesis under Solvent-Free Reaction

2020-8-6  One of the most thoroughly studied organocatalytic reactions is the aldol reaction, since it constitutes one of the most useful strategies for the formation of C-C bonds. In a seminal work reported in 2006, Bolm et al. carried out asymmetric aldol reactions by means of chiral organocatalysts in a ball mill with excellent results [57,58].

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Ball milling for the quantitative and specific solvent ...

Ball milling is used as a facile, efficient, cheap, and environmentally friendly procedure for the solvent-free three-component reaction of aromatic aldehydes with malononitrile and dimedone, or 1,3-cyclohexanedione, resorcinol, and α- and β-naphthol. The reactions

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Recent Strategies in the Synthesis of Spiroindole and ...

2021-5-18  After the aldol procedure in a one-pot process, substrate 110 could be readily involved with three equivalents of NCS and converted to dearomatizated product 111 in 76% efficiency and 94% ee. Furthermore, high diastereoselectivity was acquired due to the steric strain of

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Organocatalysis in aqueous media Nature Reviews

2019-7-17  Another remarkable enzyme-inspired aldol reaction involves the organocatalyst–cyclodextrin hybrid 13 (Supplementary Table 1, reaction 4b), which promotes asymmetric direct aldol reactions with ...

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许丹倩 - 浙江工业大学 - 化学工程学院 - X-MOL

IF:4.45 (4) An Organocatalytic Domino Thia-Michael/Aldol Condensation Reaction: Highly Enantioselective Synthesis of Functionalized Dihydrothiophenes, Adv. Synth. Catal., 2010, 352, 2121. IF:6.048 (5) Fast, solvent-free and hydrogen-bonding-mediated asymmetric Michael addition in a ball mill, Green Chem., 2012, 14 (4), 893.

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Mechanochemical Synthesis and Reactivity of 1,2,3

2021-4-24  The deprotection of the resulting triazole derivatives was effected by treatment with 4M hydrochloric acid in methanol under reflux. Results and Discussion: A short and convenient route to synthesize carbohydrate-derived triazoles, based in a ball-mill via 1,3-dipolar cycloaddition reactions to prop-2-yn-1-ol was developed.

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A Cu(II)–ATP complex efficiently catalyses ...

2020-9-22  ATP acts as a co-substrate in enzyme catalysed reactions, but can also specifically bind metal ions. Here, the authors show that ATP interacts with copper ions and forms a

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许丹倩_百度百科

2006-7-26  许丹倩 博士、研究员、博士生导师。1963年出生,1989年毕业于华东师范大学。1992年至今,浙江工业大学任教。主要学术荣誉称号: 省“151人才工程”第一层次。

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浙工大化学工程与材料学院导师介绍:许丹倩_浙江工业大学 ...

2013-12-1  浙工大化学工程与材料学院导师介绍:许丹倩. 1989年毕业于华东师范大学。. 1992年至今,浙江工业大学从事科研和教学工作。. 浙江省重中之重一级学科方向负责人,浙江省重点科技创新团队方向负责人,浙江省高等学校创新团队负责人;中国氟硅有机材料工业 ...

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